A concise review- An analytical method development and validation of loratadine

• Author Details:   
• Pritam Jain ^*
• Ashish Chaudhari
• Udaysing Girase
• Nitin Haswani

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One to one and a half hours is when peak plasma concentrations of the long-acting antihistamine loratadine, which is quickly absorbed when taken orally, reach. There is no discernible buildup after repeated dosages, and its pharmacokinetics are dose proportional. Similar in its kinetics, descarboethoxy-loratadine (DCL), the primary metabolite, is likewise pharmacologically active. Poop and urine are the main ways that the medication is eliminated after significant metabolism.

This study focuses on the most current advancements in analytical methods for figuring out the presence of loratadine in different biological media, such as human plasma and urine, as well as in bulk and commercial dose forms. High performance liquid chromatography (HPLC), high performance thin layer chromatography (HPTLC), liquid chromatography linked to tandem mass spectrometry (LC-MS), and electrophoresis will all be thoroughly examined in this paper. Matrix, stationary phase, mobile phase composition, RF value for detection wavelength, retention time, DL, carrier gas, flow rate, capillaries wavelength, separation voltage, temperature, and pressure are some of the factors that are included in these procedures.